In addition to the already discovered potential of cannabidiol to ward off the inflammatory cytokine storm associated with severe COVID-19 cases, a new study from Oregon State researchers found that CBDA and one of its hemp-based neighbors can actually prevent the virus from infecting some cells.
As the research team discovered, CBDA possesses a “micromolar affinity” for the SARS-CoV-2 spike protein, attaching itself as a ligand to the protein and preventing infection of certain cell types.
Particularly, the Oregon State researchers proved that this affinity of CBDA for the spike protein prevented the virus from infecting epithelial cells, which form the outer layers of tissues and structures throughout the body.
In order to demonstrate this, the researchers conducted what’s called a “follow-up virus neutralization assay,” a test that allowed them to analyze the effects of CBDA on the spike protein without cross-reactions (takes place outside of the body).
Importantly, the researchers noted that, in addition to cannabidiolic acid, cannabigerolic acid was “equally effective against the SARS-Cov-2 alpha variant B.1.1.7 and the beta variant B.1.351.”
When paired with the formerly discovered ability of CBD to mediate the effects of the overactive inflammatory response (acute respiratory distress syndrome) associated with some COVID-19 cases, this ability of CBDA and CBGA to prevent entry into host cells in the first place bodes very well for the hemp compounds as safe and generally well-tolerated treatments for the virus.
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